ABSTRACT
The advent and spread of novel coronavirus viruses (nCoV), has been presenting the planet with a new public health crisis since December 2019. Several cases of unexplained pneumonia occurred in Wuhan, Hubei Province, China, only a month before the Chinese Spring festival. After a diagnosis of broncho-alveolar fluid samples of people from the Wuhan Seafood Market, the new coronavirus was identified using next-generation sequence technology. This work aims to bring out information regarding COVID-19 under a common platform that will help the researchers to identify the vital therapeutic targets for SARS-CoV-2 and, also it will provide insights into some significant work performed in recent times by scientific communities around the globe. In this review, we have tried to explore multiple aspects related to COVID-19 that includes: Epidemiology, Etiology, COVID-19 variants, Vaccine candidates, Potential therapeutic targets, role of natural products, and computational studies in drug design and development, repurposing, analysis of crystal structures available for COVID-19 related protein structures. Druggable targets include all viral enzymes and proteins involved in viral replication and regulation of host cellular machines. The medical community is tracking several therapies to combat the infection by using various antiviral and immunomodulatory mechanisms. While some vaccines are approved in this world-wide health crisis, a more precise therapy or drug is formally recommended to be used against SARS-CoV-2 infection. Natural products other than synthetic drugs, have been tested by in silico analysis against COVID-19. However, important issues still need to be addressed regarding in vivo bioavailability and better efficacy.